Proanthocyanidins from Barley Bran Potentiate Retinoic Acid-induced Granulocytic and Sodium Butyrate-induced Monocytic Differentiation of HL60 Cells

Koji TAMAGAWA; Sei FUKUSHIMA; Masuko KOBORI; Hiroshi SHINMOTO; Tojiro TSUSHIDA

doi:10.1271/bbb.62.1483

Food & Nutrition Science Regular Papers

Proanthocyanidins from Barley Bran Potentiate Retinoic Acid-induced Granulocytic and Sodium Butyrate-induced Monocytic Differentiation of HL60 Cells

Koji TAMAGAWA, Sei FUKUSHIMA, Masuko KOBORI, Hiroshi SHINMOTO, Tojiro TSUSHIDA

著者情報

キーワード: proanthocyanidins, barley bran, differentiation, HL60 cells

ジャーナルフリー

1998 年 62 巻 8 号 p. 1483-1487

DOI https://doi.org/10.1271/bbb.62.1483

詳細

抄録

Polyphenol extract from barley bran (BPE) induced nitro blue tetrazolium (NBT) reducing activity and alpha-naphthyl butyrate esterase activity in HL60 human myeloid leukemia cells. Because BPE induced the biochemical markers of HL60 cell differentiation, we investigated the effects of proanthocyanidins isolated from BPE on the HL60 cell differentiation of HL60 cells. Prodelphinidin B-3, T1, T2, and T3 induced 26-40% NBT-positive cells and 22-32% alpha-naphthyl butyrate esterase-positive cells. Proanthocyanidins potentiated retinoic acid (all-trans-retinoic acid)-induced granulocytic and sodium butyrate-induced monocytic differentiation in HL60 cells.

責任著者(Corresponding author)

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