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Bioscience, Biotechnology, and Biochemistry
Vol. 62 (1998) No. 9 P 1819-1821



Food & Nutrition Science Notes

  The mechanisms for tight-junction (TJ) stabilization by β-lactoglobulin (β-Lg) were studied. Treatment of Caco-2-SF cells with inhibitors for some enzymes in the intracellular signal transduction pathways and a cytoskeleton-disturbing agent (cytochalasin D) reduced the TJ-stabilizing activity of β-Lg. So β-Lg is suggested to modulate the cytoskeletal structure through the activation of phospholipase C and protein kinase C, resulting in the TJ stabilization.

Copyright © 1998 by Japan Society for Bioscience, Biotechnology, and Agrochemistry

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