A High-Mr Glycoprotein Fraction from Cow’s Milk Potent in Inhibiting Replication of Human Rotavirus in Vitro

Yoshihiro KANAMARU; Michiko ETOH; Xiang-Guang SONG; Takashi MIKOGAMI; Hirotoshi HAYASAWA; Takusaburo EBINA; Nobuyuki MINAMOTO

doi:10.1271/bbb.63.246

Food & Nutrition Science Preliminary Communication

A High-Mr Glycoprotein Fraction from Cow’s Milk Potent in Inhibiting Replication of Human Rotavirus in Vitro

Yoshihiro KANAMARU, Michiko ETOH, Xiang-Guang SONG, Takashi MIKOGAMI, Hirotoshi HAYASAWA, Takusaburo EBINA, Nobuyuki MINAMOTO

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Keywords: cow’s milk, milk mucin, glycoprotein, human rotavirus, neutralization

JOURNAL FREE ACCESS

1999 Volume 63 Issue 1 Pages 246-249

DOI https://doi.org/10.1271/bbb.63.246

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Abstract

Rotavirus is the major cause of infectious diarrhea in infants and young children all over the world. We have found that a high-M_r glycoprotein fraction from cow’s milk is potent in inhibiting replication of human rotaviruses in vitro. Since the activity seems to be unique and specific, this fraction may be useful as a novel agent for treatment or prevention of rotavirus diarrhea.

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