1999 年 63 巻 12 号 p. 2248-2251
The phosphonodifluoromethyl ketone and phosphonofluoridate derivatives of L-glutamic acid were synthesized and characterized as analogues of the γ-glutamyl phosphate intermediate and the tetrahedral transition state, respectively, for the inhibition of γ-glutamylcysteine synthetase and glutamine synthetase. The former served as a poor inhibitor of both enzymes, but the latter inhibited glutamine synthetase with a Ki of 59 μM and partially inactivated the enzyme in an NH3- and ATP-dependent manner.
この記事は最新の被引用情報を取得できません。