Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Microbiology & Fermentation Technology Regular Papers
In Vitro Anti-Human Immunodeficiency Virus Activity of Polysaccharide from Rhizophora mucronata Poir.
Mariappan PREMANATHANKandasamy KATHIRESANNaoki YAMAMOTOHideki NAKASHIMA
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1999 Volume 63 Issue 7 Pages 1187-1191

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Abstract

  A polysaccharide was extracted with 1% sodium carbonate from the bark of Rhizophora mucronata and its antiviral activities against human immunodeficiency virus (HIV) were assessed by an in vitro cell culture system. The anti-HIV activity of the alkaline extract was mainly recovered in the 25-75% ethanol-precipitated fraction. Rhizophora mucronata polysaccharide (RMP) protected MT-4 cells from the HIV-induced cytopathogenicity and blocked the expression of HIV antigens. RMP completely inhibited the viral binding to the cell and the formation of syncytium upon cocultivation of MOLT-4/HIV-1IIIB cells and MOLT-4 cells. These results suggest that RMP inhibited early steps of the virus life cycle especially virus adsorption to the cell.

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© 1999 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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