Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Notes
Natural Antioxidant, Chlorogenic Acid, Protects Against DNA Breakage Caused by Monochloramine
Hitoshi SHIBATAYuji SAKAMOTOMikiko OKAYasuhisa KONO
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JOURNALS FREE ACCESS

1999 Volume 63 Issue 7 Pages 1295-1297

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Abstract

  Chlorogenic acid prevented a stepwise conversion of plasmid pUC18 DNA, form I→form II→form III, induced by 3 mM monochloramine with a half inhibition of 67.4 μM. Chlorogenic acid reacted with monochloramine in a time-dependent manner, and the reaction rate increased with decreasing pH. These results suggest that chlorogenic acid prevents genotoxicity of monochloramine in gastric mucosa.

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© 1999 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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