Positional Isomers of Monohydroperoxides Produced by Peroxidation of Phosphatidylcholine Containing an Arachidonoyl Moiety in a Liposomal Suspension

Abstract

  Monohydroperoxides derived from the peroxidation of 1-palmitoyl-2-arachidonoyl-phosphatidylcholine (PC-AA) in a liposomal suspension had a characteristic isomeric composition. Of the two possible isomers derived from a pentadienyl-radical intermediate, the isomer with a hydroperoxy group on the carboxyl-terminal side was at a substantially lower level than the other.