Amplifing Effect of Dietary Taurine on the Induction of Cytochrome P-450 and on the Urinary Excretion of Ascorbic Acid in Rats Fed on Phenobarbital-containing Diets

Hideki MOCHIZUKI; Jun TAKIDO; Hiroaki ODA; Hidehiko YOKOGOSHI

doi:10.1271/bbb.64.405

Food & Nutrition Science Notes

Amplifing Effect of Dietary Taurine on the Induction of Cytochrome P-450 and on the Urinary Excretion of Ascorbic Acid in Rats Fed on Phenobarbital-containing Diets

Hideki MOCHIZUKI, Jun TAKIDO, Hiroaki ODA, Hidehiko YOKOGOSHI

著者情報

キーワード: taurine, phenobarbital, cytochrome P-450, ascorbic acid, xenobiotics

ジャーナルフリー

2000 年 64 巻 2 号 p. 405-407

DOI https://doi.org/10.1271/bbb.64.405

詳細

抄録

Dietary taurine amplified the induction of cytochrome P-450 and the urinary excretion of ascorbic acid in rats fed on phenobarbital (PB)-containing diets. These facts suggest that taurine could influence the hepatic metabolism of xenobiotics via the induction of drug-metabolizing enzymes (DME) and the ascorbic acid metabolism. Taurine might improve the function of DME exposed by some xenobiotics.

責任著者(Corresponding author)

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