Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Biochemistry & Molecular Biology Preliminary Communication
An Automated System for Genome Analysis to Support Microbial Whole-genome Shotgun Sequencing
Tokuki SAKIYAMAHideto TAKAMINaotake OGASAWARASatoru KUHARATokio KOZUKIKosuke DOGAAkira OHYAMAKoki HORIKOSHI
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Volume 64 (2000) Issue 3 Pages 670-673

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Abstract

  We developed a semi-automated genome analysis system called GAMBLER in order to support the current whole-genome sequencing project focusing on alkaliphilic Bacillus halodurans C-125. GAMBLER was designed to reduce the human intervention required and to reduce the complications in annotating thousands of ORFs in the microbial genome. GAMBLER automates three major routines: analyzing assembly results provided by genome assembler software, assigning ORFs, and homology searching. GAMBLER is equipped with an interface for convenience of annotation. All processes and options are manipulatable through a WWW browser that enables scientists to share their genome analysis results without choosing computer platforms.

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© 2000 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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