Identification and Characterization of a Potent Antibacterial Agent, NH125 against Drug-resistant Bacteria

Kaneyoshi YAMAMOTO; Takashi KITAYAMA; Noriyasu ISHIDA; Takafumi WATANABE; Hiroyuki TANABE; Masahiro TAKATANI; Tadashi OKAMOTO; Ryutaro UTSUMI

doi:10.1271/bbb.64.919

Biochemistry & Molecular Biology Notes

Identification and Characterization of a Potent Antibacterial Agent, NH125 against Drug-resistant Bacteria

Kaneyoshi YAMAMOTO, Takashi KITAYAMA, Noriyasu ISHIDA, Takafumi WATANABE, Hiroyuki TANABE, Masahiro TAKATANI, Tadashi OKAMOTO, Ryutaro UTSUMI

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Keywords: drug-resistant pathogens, histidine protein kinase, two-component system, bacterial signal transduction

JOURNAL FREE ACCESS

2000 Volume 64 Issue 4 Pages 919-923

DOI https://doi.org/10.1271/bbb.64.919

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Abstract

New imidazole compounds were synthesized to develop a novel and effective antibacterial agent (1-benzyl-3-cetyl-2-methylimidazolium iodide, NH125). In vitro experiments demonstrated that NH125 effectively inhibited a number of different histidine protein kinases. Furthermore, oxacillin-resistant Staphylococcus aureus (ORSA), vancomycin-resistant Enterococcus faecalis (VRE), penicillin-resistant Streptococcus pneumoniae (PRS), and other Gram-positive and Gram-negative bacteria were found to be very sensitive to NH125.

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