1,1-Diphenyl-2-picrylhydrazyl Radical-scavenging Compounds from Soybean Miso and Antiproliferative Activity of Isoflavones from Soybean Miso toward the Cancer Cell Lines

Abstract

  Guided by their DPPH radical-scavenging activity, nine compounds were isolated from soybean miso. Of these, 8-hydroxydaidzein, 8-hydroxygenistein and syringic acid had as high DPPH radical-scavenging activity as that of α-tocopherol. The antiproliferative activity of four of the isolated isoflavones toward three cancer cell lines was examined. 8-Hydroxygenistein showed the highest activity (IC₅₀=5.2 μM) toward human promyelocytic leukemia cells (HL-60).