Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Biochemistry & Molecular Biology Preliminary Communication
mRNA Expression of MT1-MMP, MMP-9, Cathepsin K, and TRAP in Highly Enriched Osteoclasts Cultured on Several Matrix Proteins and Ivory Surfaces
Toshimasa UEMURAYin-kun LIUYoshinori KUBOKI
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JOURNAL FREE ACCESS

2000 Volume 64 Issue 8 Pages 1771-1773

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Abstract

  We demonstrated that the transcriptional expression of MT1-MMP, MMP-9, cathepsin K, and TRAP in highly enriched osteoclasts were regulated by different matrix proteins that bind to integrin on osteoclast, such as collagen type I (CoI), fibronectin (FN), vitronectin (VN), osteopontin (OPN), and ivory. Results suggested that the OPN-integrin αVβ3 binding plays a more important role than CoI-α2β1 binding in the regulation of osteoclast activity.

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© 2000 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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