2000 Volume 64 Issue 8 Pages 1771-1773
We demonstrated that the transcriptional expression of MT1-MMP, MMP-9, cathepsin K, and TRAP in highly enriched osteoclasts were regulated by different matrix proteins that bind to integrin on osteoclast, such as collagen type I (CoI), fibronectin (FN), vitronectin (VN), osteopontin (OPN), and ivory. Results suggested that the OPN-integrin αVβ3 binding plays a more important role than CoI-α2β1 binding in the regulation of osteoclast activity.
This article cannot obtain the latest cited-by information.