Protective Effect of Ajoene on Acetaminophen-induced Hepatic Injury in Mice

Atsuhiko HATTORI; Norihiko YAMADA; Tomoaki NISHIKAWA; Hiroyuki FUKUDA; Tsuchiyoshi FUJINO

doi:10.1271/bbb.65.2555

Food & Nutrition Science

Protective Effect of Ajoene on Acetaminophen-induced Hepatic Injury in Mice

Atsuhiko HATTORI, Norihiko YAMADA, Tomoaki NISHIKAWA, Hiroyuki FUKUDA, Tsuchiyoshi FUJINO

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Keywords: acetaminophen, hepatoprotective effect, ajoene, garlic, Allium sativum

JOURNAL FREE ACCESS

2001 Volume 65 Issue 11 Pages 2555-2557

DOI https://doi.org/10.1271/bbb.65.2555

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Abstract

Ajoene, a garlic-derived sulfur-containing compound, exhibited a hepatoprotective effect against acetaminophen-induced liver injury in mice. A pretreatment with ajoene suppressed the rise in serum glutamicpyruvic transaminase activity and the reduction in the hepatic reduced glutathione level. These effects of ajoene were observed dose-dependently (20-100 mg/kg). The pretreatment by ajoene also suppressed the decrease in hepatic protein thiol content resulting from acetaminophen administration.

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