Glycitein Effect on Suppressing the Proliferation and Stimulating the Differentiation of Osteoblastic MC3T3-E1 Cells

Hiroyuki YOSHIDA; Takanori TERAMOTO; Katsumi IKEDA; Yukio YAMORI

doi:10.1271/bbb.65.1211

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Food & Nutrition Science

Glycitein Effect on Suppressing the Proliferation and Stimulating the Differentiation of Osteoblastic MC3T3-E1 Cells

Hiroyuki YOSHIDA, Takanori TERAMOTO, Katsumi IKEDA, Yukio YAMORI

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Keywords: glycitein, isoflavone, alkaline phosphatase, osteocalcin

JOURNAL FREE ACCESS

2001 Volume 65 Issue 5 Pages 1211-1213

DOI https://doi.org/10.1271/bbb.65.1211

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Abstract

Glycitein, as one of the three major isoflavones in soybeans, directly but significantly (about 50%) suppressed the proliferation of MC3T3-E1 and stimulated bone-related protein (alkaline phosphatase (ALP) and osteocalcin (OC)) expression. These results indicate that glycitein suppresses the proliferation of osteoblasts and promotes differentiation from its progenitor.

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