Enzymatic Glycosylation of Lincomycin

Lenka WEIGNEROVÁ; Jaroslav SPÍZEK; Lucie NAJMANOVÁ; Vladimír KREN

doi:10.1271/bbb.65.1897

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Biochemistry & Molecular Biology

Enzymatic Glycosylation of Lincomycin

Lenka WEIGNEROVÁ, Jaroslav SPÍZEK, Lucie NAJMANOVÁ, Vladimír KREN

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Keywords: lincomycin, enzymatic glycosylation, mannosylation

JOURNAL FREE ACCESS

2001 Volume 65 Issue 8 Pages 1897-1899

DOI https://doi.org/10.1271/bbb.65.1897

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Abstract

Lincomycin (1), a glycosidic antibiotic, active against Gram-positive bacteria, was modified enzymatically with the aim of improving its physico-chemical and biological properties. Compound 1 was glycosylated using jack bean α-mannosidase to produce 7-O-α-D-mannopyranosyl-lincomycin (2).

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