Isolation and Identification of Dihydrochrysanolide and Its 1-Epimer from Chrysanthemum coronarium L.

Kyung Dong LEE; Min Suk YANG; Tae Jung HA; Ki Min PARK; Ki Hun PARK

doi:10.1271/bbb.66.862

Organic Chemistry Notes

Isolation and Identification of Dihydrochrysanolide and Its 1-Epimer from Chrysanthemum coronarium L.

Kyung Dong LEE, Min Suk YANG, Tae Jung HA, Ki Min PARK, Ki Hun PARK

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Keywords: Chrysanthemum coronarium L., sesquiterpene lactone, dihydrochrysanolide, 1-epi-dihydrochrysanolide, cytotoxic activity

JOURNAL FREE ACCESS

2002 Volume 66 Issue 4 Pages 862-865

DOI https://doi.org/10.1271/bbb.66.862

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Abstract

A new sesquiterpene lactone (1) was isolated with known dihydrochrysanolide derivatives (2 and 3) from the flowers of Chrysanthemum coronarium L., and their structures were identified by spectroscopic data. The stereochemistry of the epimers (1 and 2) was determined from NOESY data and an X-ray crystallographic analysis. The isolated compounds (1–3) were examined for their cytotoxic activity against such human cell lines as A549, PC-3 and HCT-15.

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