Suppressive Effect of Polysaccharides from the Edible and Medicinal Mushrooms, Lentinus edodes and Agaricus blazei, on the Expression of Cytochrome P450s in Mice

Takashi HASHIMOTO; Yuji NONAKA; Ken-ichiro MINATO; Sachiko KAWAKAMI; Masashi MIZUNO; Itsuko FUKUDA; Kazuki KANAZAWA; Hitoshi ASHIDA

doi:10.1271/bbb.66.1610

Food & Nutrition Science Preliminary Communication

Suppressive Effect of Polysaccharides from the Edible and Medicinal Mushrooms, Lentinus edodes and Agaricus blazei, on the Expression of Cytochrome P450s in Mice

Takashi HASHIMOTO, Yuji NONAKA, Ken-ichiro MINATO, Sachiko KAWAKAMI, Masashi MIZUNO, Itsuko FUKUDA, Kazuki KANAZAWA, Hitoshi ASHIDA

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Keywords: lentinan, Lentinas edodes, Agaricus blazei polysaccharides, cytochrome P450, tumor necrosis factor-α (TNF-α)

JOURNAL FREE ACCESS

2002 Volume 66 Issue 7 Pages 1610-1614

DOI https://doi.org/10.1271/bbb.66.1610

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Abstract

To investigate the effects of lentinan from Lentinas edodes and polysaccharides from Agaricus blazei (ABPS) on the expression of cytochrome P450s (CYPs), lentinan (10 mg/kg/day) or ABPS (200 mg/kg/day) was administered to female BALB/c mice four times every other day by intraperitoneal injection. Lentinan and ABPS suppressed both the constitutive and 3-methylcholanthrene-induced CYP1A expression and ethoxyresorufin-O-deethylation activity in the liver.

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