Nuclear Localization of Senescence Marker Protein-30, SMP30, in Cultured Mouse Hepatocytes and Its Similarity to RNA Polymerase

Akihito ISHIGAMI; Setsuko HANDA; Naoki MARUYAMA; Prakash C. SUPAKAR

doi:10.1271/bbb.67.158

Biochemistry & Molecular Biology Notes

Nuclear Localization of Senescence Marker Protein-30, SMP30, in Cultured Mouse Hepatocytes and Its Similarity to RNA Polymerase

Akihito ISHIGAMI, Setsuko HANDA, Naoki MARUYAMA, Prakash C. SUPAKAR

著者情報

キーワード: SMP30, nuclear localization

ジャーナルフリー

2003 年 67 巻 1 号 p. 158-160

DOI https://doi.org/10.1271/bbb.67.158

詳細

抄録

Senescence marker protein-30 (SMP30), expressed mostly in the liver, protects cells against various injuries by stimulating membrane calcium-pump activity. By immunohistochemistry and western blotting, we found that SMP30 was in both the nuclei and cytoplasm of cultured mouse hepatocytes. By a homology search, we found that a domain of the SMP30 sequence 51 amino acid residues long was 60-66% similar to bacterial and yeast RNA polymerases.

責任著者(Corresponding author)

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