2003 Volume 67 Issue 11 Pages 2455-2458
We examined the effects of serum deprivation on myofibrillar proteolysis in chick myotubes. Myotubes were incubated with serum-free medium for 24 hours. Nτ-methylhistidine release, as an index of myofibrillar proteolysis, as well as protease activities such as calpain, proteasome, and cathepsins (B+L and D) activities were increased by serum deprivation. These results indicate that serum deprivation induces calpain, proteaosme, and cathepsins activities, resulting in an increase in myofibrillar proteolysis in chick myotubes.
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