Suppression by Hydrangeae Dulcis Folium of <small>D</small>-Galactosamine-induced Liver Injury in Vitro and in Vivo

Ryusuke NAKAGIRI; Erika HASHIZUME; Shun KAYAHASHI; Yasushi SAKAI; Toshikazu KAMIYA

doi:10.1271/bbb.67.2641

Food & Nutrition Science Note

Suppression by Hydrangeae Dulcis Folium of D-Galactosamine-induced Liver Injury in Vitro and in Vivo

Ryusuke NAKAGIRI, Erika HASHIZUME, Shun KAYAHASHI, Yasushi SAKAI, Toshikazu KAMIYA

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Keywords: hepatocyte, hepatoprotective, liver injury, Hydrangeae Dulcis Folium, D-galactosamine

JOURNAL FREE ACCESS

2003 Volume 67 Issue 12 Pages 2641-2643

DOI https://doi.org/10.1271/bbb.67.2641

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Abstract

Hydrangeae Dulcis Folium, the fermented and dried leaves of Hydrangea macrophylla SER. var. thunbergii MAKINO, suppressed D-galactosamine-induced liver injury by 85.2% when added to the diet at 1% and fed to rats for fifteen days. The hepatoprotective effect is more potent than that of a milk thistle extract and turmeric powder. Some fractionated extracts showed hepatoprotective activity in the D-galactosamine-induced in vitro liver injury model.

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