Determination of the Absolute Configuration of (+)-Xestoaminol C [(2S, 3R)-2-Amino-3-tetradecanol], a Metabolite of Fiji Sponge, Xestospongia sp., by the Synthesis of Its…

Abstract

  The N,O-diacetyl derivative of (+)-xestoaminol C (2-amino-3-tetradecanol, 1), an inhibitor of reverse transcriptase isolated from Xestospongia sp., was synthesized from (S)-alanine, and its absolute configuration was determined as 2S, 3R.