Effect of α-Tocopherol on the Oxidative Modification of Apolipoprotein E in Human Very-low-density Lipoprotein

Hirofumi ARAI; Koji UCHIDA; Kenji FUKUNAGA; Yuji NAGASAKA; Satoshi MOHRI; Hiroko FURUMOTO; Yasuhiro KURAMITSU; Kazuyuki NAKAMURA

doi:10.1271/bbb.67.402

Food & Nutrition Science Notes

Effect of α-Tocopherol on the Oxidative Modification of Apolipoprotein E in Human Very-low-density Lipoprotein

Hirofumi ARAI, Koji UCHIDA, Kenji FUKUNAGA, Yuji NAGASAKA, Satoshi MOHRI, Hiroko FURUMOTO, Yasuhiro KURAMITSU, Kazuyuki NAKAMURA

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Keywords: apolipoprotein E, oxidation, α-tocopherol, very-low-density lipoprotein

JOURNAL FREE ACCESS

2003 Volume 67 Issue 2 Pages 402-405

DOI https://doi.org/10.1271/bbb.67.402

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Abstract

The oxidative modification of apolipoprotein (apo) E and lipid peroxidation in human very-low-density lipoprotein (VLDL) induced by peroxynitrite and cupric ions in vitro were strongly suppressed by enrichment with α-tocopherol (α-Toc; 170 μM). α-Toc also suppressed the decrease in the heparin-binding activity of apoE in the VLDL oxidation. These results suggest that α-Toc protected apoE in VLDL from oxidative stress.

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