Effect of α-Tocopherol on the Oxidative Modification of Apolipoprotein E in Human Very-low-density Lipoprotein

Hirofumi ARAI; Koji UCHIDA; Kenji FUKUNAGA; Yuji NAGASAKA; Satoshi MOHRI; Hiroko FURUMOTO; Yasuhiro KURAMITSU; Kazuyuki NAKAMURA

doi:10.1271/bbb.67.402

Food & Nutrition Science Notes

Effect of α-Tocopherol on the Oxidative Modification of Apolipoprotein E in Human Very-low-density Lipoprotein

Hirofumi ARAI, Koji UCHIDA, Kenji FUKUNAGA, Yuji NAGASAKA, Satoshi MOHRI, Hiroko FURUMOTO, Yasuhiro KURAMITSU, Kazuyuki NAKAMURA

Author information

Hirofumi ARAI
Department of Biochemistry and Biomolecular Recognition, Yamaguchi University School of Medicine
Koji UCHIDA
Laboratory of Food and Biodynamics, Nagoya University School of Agricultural Science
Kenji FUKUNAGA
Department of Public Health, Kansai Medical University
Yuji NAGASAKA
Department of Nutrition, Yamaguchi Prefectural University
Satoshi MOHRI
Industrial Technology Institute, Miyagi Prefectural Government
Hiroko FURUMOTO
Department of Biochemistry and Biomolecular Recognition, Yamaguchi University School of Medicine
Yasuhiro KURAMITSU
Department of Biochemistry and Biomolecular Recognition, Yamaguchi University School of Medicine
Kazuyuki NAKAMURA
Department of Biochemistry and Biomolecular Recognition, Yamaguchi University School of Medicine

Keywords: apolipoprotein E, oxidation, α-tocopherol, very-low-density lipoprotein

JOURNAL FREE ACCESS

2003 Volume 67 Issue 2 Pages 402-405

DOI https://doi.org/10.1271/bbb.67.402

Details

Abstract

The oxidative modification of apolipoprotein (apo) E and lipid peroxidation in human very-low-density lipoprotein (VLDL) induced by peroxynitrite and cupric ions in vitro were strongly suppressed by enrichment with α-tocopherol (α-Toc; 170 μM). α-Toc also suppressed the decrease in the heparin-binding activity of apoE in the VLDL oxidation. These results suggest that α-Toc protected apoE in VLDL from oxidative stress.

Corresponding author

Register with J-STAGE for free!