Gnetol as a Potent Tyrosinase Inhibitor from Genus Gnetum

Kenji OHGUCHI; Toshiyuki TANAKA; Ibrahim ILIYA; Tetsuro ITO; Munekazu IINUMA; Kenji MATSUMOTO; Yukihiro AKAO; Yoshinori NOZAWA

doi:10.1271/bbb.67.663

Biochemistry & Molecular Biology Preliminary Communication

Gnetol as a Potent Tyrosinase Inhibitor from Genus Gnetum

Kenji OHGUCHI, Toshiyuki TANAKA, Ibrahim ILIYA, Tetsuro ITO, Munekazu IINUMA, Kenji MATSUMOTO, Yukihiro AKAO, Yoshinori NOZAWA

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Keywords: tyrosinase, melanin, gnetaceae, gnetol

JOURNAL FREE ACCESS

2003 Volume 67 Issue 3 Pages 663-665

DOI https://doi.org/10.1271/bbb.67.663

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Abstract

Gnetol (2,3′,5′,6-tetrahydroxy-trans-stilbene), a naturally occurring compound particularly found in the genus Gnetum, had a strong inhibitory effect on murine tyrosinase activity. Gnetol (IC₅₀, 4.5 μM) was stronger than kojic acid (IC₅₀, 139 μM) as a standard inhibitor for murine tyrosinase activity. Moreover, gnetol significantly suppressed melanin biosynthesis in murine B16 melanoma cells.

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