2003 年 67 巻 6 号 p. 1401-1404
The cytotoxic activity of ethanol extracts from 53 parts of 36 species of medicinal and edible plants cultivated in Okinawa was measured by using K562 human leukemia cells by a flow cytometric method. Two extracts from Rhodea japonica and Hypericum chinense were cytotoxic at a concentration of 10 μg/ml. The main cytotoxic constituent of Rhodea japonica was isolated and identified to be rhodexin A, which has been isolated as a cardetonic agent of the plant. The IC50 value for rhodexin A against the growth of K562 cells was 19 nM, this activity being much stronger than that of ouabain (IC50, 60 nM).
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