Three New Cytotoxic Acylspermidines from the Soft Coral, Sinularia sp.

Makoto OJIKA; Mohammad Kamrul ISLAM; Tomoaki SHINTANI; Yang ZHANG; Tetsuji OKAMOTO; Youji SAKAGAMI

doi:10.1271/bbb.67.1410

Organic Chemistry Notes

Three New Cytotoxic Acylspermidines from the Soft Coral, Sinularia sp.

Makoto OJIKA, Mohammad Kamrul ISLAM, Tomoaki SHINTANI, Yang ZHANG, Tetsuji OKAMOTO, Youji SAKAGAMI

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Keywords: spermidine, Sinularia, marine natural products, cytotoxicity, apoptosis

JOURNAL FREE ACCESS

2003 Volume 67 Issue 6 Pages 1410-1412

DOI https://doi.org/10.1271/bbb.67.1410

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Abstract

Three new acylated spermidines and two known related compounds were isolated from the Okinawan soft coral, Sinularia sp. These compounds were N′,N″,N″-trimethylspermidines that are acylated by a methyl-branched unsaturated fatty acid. These acylspermidines showed potent cytotoxicity against human tumor cell lines at an IC₅₀ value of 17 ng/ml and the induction of apoptotic phenomena.

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