Myrsinoic Acid E, an Anti-inflammatory Compound from Myrsine seguinii

Hidefumi MAKABE; Shintaro MIYAZAKI; Tsunashi KAMO; Mitsuru HIROTA

doi:10.1271/bbb.67.2038

Organic Chemistry Notes

Myrsinoic Acid E, an Anti-inflammatory Compound from Myrsine seguinii

Hidefumi MAKABE, Shintaro MIYAZAKI, Tsunashi KAMO, Mitsuru HIROTA

著者情報

キーワード: anti-inflammatory, Myrsine seguinii; 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced edema, Pd-catalyzed carbonylation

ジャーナルフリー

2003 年 67 巻 9 号 p. 2038-2041

DOI https://doi.org/10.1271/bbb.67.2038

詳細

抄録

The methanolic extract of Myrsine seguinii yielded the novel anti-inflammatory compound, myrsinoic acid E (1), whose structure was elucidated to be 3,5-digeranyl-4-hydroxy benzoic acid. We synthesized 1- and its 3,5-diprenyl (2) and 3,5-difarnesyl analogues (3). Compounds 1-3 suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation of mouse ears by 59%, 14%, and 69% at a dose of 1.4 μmol.

責任著者(Corresponding author)

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