Mac1 Positive Cells Are Required for Enhancement of Splenocytes Proliferation Caused by Bisphenol A

Masao GOTO; Hiroshi ONO; Yuko TAKANO-ISHIKAWA; Hiroshi SHINMOTO; Mitsuru YOSHIDA

doi:10.1271/bbb.68.263

Food & Nutrition Science Communication

Mac1 Positive Cells Are Required for Enhancement of Splenocytes Proliferation Caused by Bisphenol A

Masao GOTO, Hiroshi ONO, Yuko TAKANO-ISHIKAWA, Hiroshi SHINMOTO, Mitsuru YOSHIDA

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Keywords: bisphenol A, xenoestrogen, splenocytes, proliferation, Mac1

JOURNAL FREE ACCESS

2004 Volume 68 Issue 1 Pages 263-265

DOI https://doi.org/10.1271/bbb.68.263

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Abstract

We examined the effects of bisphenol A (BPA) on immune cells and it was shown that BPA upregulated the proliferation of murine splenocytes stimulated with Concanavalin A (ConA). The upregulating effects of BPA were removed with depleting Mac1⁺ cells from the splenocytes. This study provides evidence for the first time that Mac1⁺ cells were required for enhancement of splenocytes proliferation caused by bisphenol A.

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