Suppressive Effects of Natural and Synthetic Agents on Dextran Sulfate Sodium-induced Interleukin-1β Release from Murine Peritoneal Macrophages

Abstract

Interleukin (IL)-1β, an anti-apoptotic and pro-inflammatory cytokine, plays an important role in the onset of inflammation-associated disease. We examined the suppressive effects of a total of 39 synthetic or natural compounds on dextran sulfate sodium-induced IL-1β production in murine peritoneal macrophages. Several compounds, including α-tocopherol, gallic acid, (−)-catechin and rutin, were found to be highly effective for attenuating IL-1β production, suggesting that they would be useful for anti-inflammatory application.