Suppression of Dioxin Mediated Aryl Hydrocarbon Receptor Transformation by Ethanolic Extracts of Propolis

Yong K. PARK; Itsuko FUKUDA; Hitoshi ASHIDA; Shin NISHIUMI; Julio Paredes GUZMAN; Helia H. SATO; Glaucia M. PASTORE

doi:10.1271/bbb.68.935

Biochemistry & Molecular Biology Notes

Suppression of Dioxin Mediated Aryl Hydrocarbon Receptor Transformation by Ethanolic Extracts of Propolis

Yong K. PARK, Itsuko FUKUDA, Hitoshi ASHIDA, Shin NISHIUMI, Julio Paredes GUZMAN, Helia H. SATO, Glaucia M. PASTORE

著者情報

キーワード: propolis, flavonoids, aryl hydrocarbon receptor, dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

ジャーナルフリー

2004 年 68 巻 4 号 p. 935-938

DOI https://doi.org/10.1271/bbb.68.935

詳細

抄録

Present study demonstrated that the ethanolic extracts of propolis containing higher concentrations of flavonoids suppressed 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced aryl hydrocarbon receptor transformation in a dose-dependent manner. The IC₅₀ values of propolis group 3 and group 12 were 1.2 and 3.6 μg/ml, respectively, indicating that propolis showed stronger antagonistic effects as compared with vegetable extracts.

責任著者(Corresponding author)

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