Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Regular Papers
Anti-allergic Activity of Naringenin Chalcone from a Tomato Skin Extract
Taichi YAMAMOTOMineka YOSHIMURAFumio YAMAGUCHITomoko KOUCHIRyohei TSUJIMakoto SAITOAkio OBATAMamoru KIKUCHI
Author information
JOURNALS FREE ACCESS

2004 Volume 68 Issue 8 Pages 1706-1711

Details
Abstract

The anti-allergic activity of a tomato extract was studied by using an in vitro histamine-release assay. The tomato skin extract exerted the strongest inhibition of histamine release. Chlorogenic acid, rutin and naringenin were identified in the 60% ethanol extract of tomato skin. However, the extract contained an unknown compound which strongly inhibited histamine release. This active compound in tomato skin was identified as naringenin chalcone (trans-2′4′6′4-tetrahydroxychalcone). Naringenin chalcone inhibited histamine release with an IC50 value of 68 μg/ml. The anti-allergic activity of the tomato skin extract was next investigated by the in vivo mouse ear-swelling response. We found that naringenin chalcone showed the strongest inhibitory effect of the polyphenols of the tomato skin extract. These results indicate that a tomato skin extract could inhibit allergic reactions.

Information related to the author

This article cannot obtain the latest cited-by information.

© 2004 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
Previous article Next article
feedback
Top