Erinacol (Cyatha-3,12-dien-14β-ol) and 11-O-Acetylcyathin A3, New Cyathane Metabolites from an Erinacine Q-Producing Hericium erinaceum

Hiromichi KENMOKU; Kazumi TANAKA; Katsuhide OKADA; Nobuo KATO; Takeshi SASSA

doi:10.1271/bbb.68.1786

Organic Chemistry Note

Erinacol (Cyatha-3,12-dien-14β-ol) and 11-O-Acetylcyathin A₃, New Cyathane Metabolites from an Erinacine Q-Producing Hericium erinaceum

Hiromichi KENMOKU, Kazumi TANAKA, Katsuhide OKADA, Nobuo KATO, Takeshi SASSA

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Keywords: erinacol, cyathane, erinacine Q, 11-O-acetylcyathin A₃, Hericium erinaceum

JOURNAL FREE ACCESS

2004 Volume 68 Issue 8 Pages 1786-1789

DOI https://doi.org/10.1271/bbb.68.1786

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Abstract

In our search for new cyathane metabolites related to the biosynthesis of erinacine Q in Hericium erinaceum, we isolated a novel cyatha-3,12-dien-14β-ol named erinacol together with known 11-O-acetylcyathatriol (the erinacine Q aglycon) and new metabolite 11-O-acetylcyathin A₃ from the mycelial extract. The structure of each compound was determined by spectral methods. Possible biosynthetic relationships of these metabolites are discussed from their structural features.

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