A Role of Androgen Receptor Protein in Cell Growth of an Androgen-Independent Prostate Cancer Cell Line

Takashi FURUTANI; Ken-ichi TAKEYAMA; Hiroshi KOUTOKU; Saya ITO; Nobuaki TANIGUCHI; Eriko SUZUKI; Masafumi KUDOH; Masayuki SHIBASAKI; Hisataka SHIKAMA; Shigeaki KATO

doi:10.1271/bbb.69.2236

Biochemistry & Molecular Biology Notes

A Role of Androgen Receptor Protein in Cell Growth of an Androgen-Independent Prostate Cancer Cell Line

Takashi FURUTANI, Ken-ichi TAKEYAMA, Hiroshi KOUTOKU, Saya ITO, Nobuaki TANIGUCHI, Eriko SUZUKI, Masafumi KUDOH, Masayuki SHIBASAKI, Hisataka SHIKAMA, Shigeaki KATO

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Keywords: prostate cancer, androgen receptor, androgen receptor antagonist

JOURNAL FREE ACCESS

2005 Volume 69 Issue 11 Pages 2236-2239

DOI https://doi.org/10.1271/bbb.69.2236

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Abstract

Prostate cancer, which develops due to androgen and is initially responsive to androgen deprivation therapy, often comes to acquire androgen deprivation therapy resistance in short order. We investigated the role of androgen receptor (AR) protein in an androgen-independent prostate cancer cell line using AR ligands and AR siRNA. Although the androgen-independent cell line scarcely responded to AR ligands, their growth was attenuated by ablation of AR protein by siRNA.

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