Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Regular Papers
Short-Term Feeding of Fish Oil Down-Regulates the Expression of Pyruvate Dehydrogenase E1 Alpha Subunit mRNA in Mouse Brain
Yoshihito NOGUSANoriyuki YANAKANaoki SUMIYOSHIYurika KASEDANobuyo TSUBOYAMA-KASAOKAOsamu EZAKINorihisa KATO
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2005 Volume 69 Issue 2 Pages 301-306

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Abstract

Previous studies have suggested that docosahexaenoic acid (DHA), contained in fish oil, prevents brain disease. In the current study, the effect of fish oil feeding on gene expression in the brain was investigated by suppression subtractive hybridization. We found that pyruvate dehydrogenase E1 alpha (PDHE1α) mRNA expression is down-regulated by fish oil feeding. We examined whether the expression of PDHE1α mRNA is altered by DHA treatment in differentiated PC12 cells. PDHE1α mRNA was reduced by supplementation of DHA with a significant decrease in cellular ATP level. These results indicate that fish oil feeding might modulate energy metabolism in the brain.

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© 2005 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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