Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Communication
Anti-Invasive Activity of Niacin and Trigonelline against Cancer Cells
Nobuhiro HIRAKAWARieko OKAUCHIYutaka MIURAKazumi YAGASAKI
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2005 Volume 69 Issue 3 Pages 653-658

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Abstract

The effects of niacin, namely, nicotinic acid and nicotinamide, and trigonelline on the proliferation and invasion of cancer cells were studied using a rat ascites hepatoma cell line of AH109A in culture. Niacin and trigonelline inhibited the invasion of hepatoma cells at concentrations of 2.5–40 μM without affecting proliferation. Hepatoma cells previously cultured with a reactive oxygen species (ROS)-generating system showed increased invasive activity. Niacin and trigonelline suppressed this ROS-potentiated invasive capacity through simultaneous treatment of AH109A cells with the ROS-generating system. The present study indicates for the first time the anti-invasive activities of niacin and trigonelline against cancer cells.

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© 2005 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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