Luteolin Inhibits Endothelin-1 Secretion in Cultured Endothelial Cells

Takaharu KOZAKAI; Akiko YAMANAKA; Toshio ICHIBA; Tetsuya TOYOKAWA; Yasuhiro KAMADA; Takako TAMAMURA; Toshiaki ICHIMURA; Susumu MARUYAMA

doi:10.1271/bbb.69.1613

Biochemistry & Molecular Biology Note

Luteolin Inhibits Endothelin-1 Secretion in Cultured Endothelial Cells

Takaharu KOZAKAI, Akiko YAMANAKA, Toshio ICHIBA, Tetsuya TOYOKAWA, Yasuhiro KAMADA, Takako TAMAMURA, Toshiaki ICHIMURA, Susumu MARUYAMA

著者情報

キーワード: endothelin, luteolin, flavonoid, secretion, gene expression

ジャーナルフリー

2005 年 69 巻 8 号 p. 1613-1615

DOI https://doi.org/10.1271/bbb.69.1613

詳細

抄録

We discovered that luteolin, a typical flavonoid contained in various kinds of plants, inhibits the secretion and gene expression of endothelin-1 (ET-1), a potent vasoconstrictor regulating blood pressure, in porcine aortic endothelial cells. Its ED₅₀ was about 10 μM. In addition, the inhibition of ET-1 by a glycoside compound of luteolin (luteolin-6-C-glucoside) was weak.

責任著者(Corresponding author)

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