Enhancement of Stress Tolerance in Saccharomyces cerevisiae by Overexpression of Ubiquitin Ligase Rsp5 and Ubiquitin-Conjugating Enzymes

Hiroyuki HIRAISHI; Mai MOCHIZUKI; Hiroshi TAKAGI

doi:10.1271/bbb.60250

Microbiology & Fermentation Technology Notes

Enhancement of Stress Tolerance in Saccharomyces cerevisiae by Overexpression of Ubiquitin Ligase Rsp5 and Ubiquitin-Conjugating Enzymes

Hiroyuki HIRAISHI, Mai MOCHIZUKI, Hiroshi TAKAGI

著者情報

キーワード: Rsp5 ubiquitin ligase, ubiquitin-conjugating enzyme, stress tolerance, Saccharomyces cerevisiae

ジャーナルフリー

2006 年 70 巻 11 号 p. 2762-2765

DOI https://doi.org/10.1271/bbb.60250

View "Advance Publication" version (November 7, 2006).

詳細

抄録

Yeast Saccharomyces cerevisiae cells overexpressing essential ubiquitin ligase Rsp5 or ubiquitin-conjugating enzymes (Ubc1-Ubc13) showed tolerance to various stresses. Co-overexpression of Rsp5 and Ubc1, Ubc2, Ubc3, Ubc5, Ubc6, Ubc9, Ubc10, Ubc11, Ubc12, or Ubc13 further enhanced stress tolerance. These results suggest that overexpression of ubiquitin-related enzymes might be a useful method for breeding novel stress-resistant strains.

責任著者(Corresponding author)

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