2006 Volume 70 Issue 6 Pages 1496-1498
We isolated and identified the glyceraldehyde-derived advanced glycation product (AGE) formed from glyceraldehyde and Nα-acetylarginine. A major product was identified as Nα-acetyl-Nδ-(5-methyl-imidazolin-4-one-2-yl)-ornithine. The compound has been reported as methylglyoxal-derived AGE, MG-H1. This study suggests that MG-H1 is formed through both glyceraldehyde-related and methylglyoxal-related pathways. There is a possibility that MG-H1 becomes an index of injury to glyceraldehyde and methylglyoxal-related enzymes.
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