Stimulation of Melanogenesis by the Citrus Flavonoid Naringenin in Mouse B16 Melanoma Cells

Abstract

Naringenin is a naturally occurring citrus flavanone. In this study, we examined the effect of naringenin on melanogenesis in mouse B16 melanoma cells. Melanin contents and tyrosinase activities were strongly increased by naringenin. Naringenin was found to cause marked increases in the expression levels of melanogenic enzymes.