Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Regular Papers
Distribution and Metabolism of Dihomo-γ-linolenic Acid (DGLA, 20:3n-6) by Oral Supplementation in Rats
Rumi UMEDA-SAWADAYoko FUJIWARAIkuko USHIYAMASatoe SAGAWAYasujiro MORIMITSUHiroshi KAWASHIMAYoshiko ONOYoshinobu KISOAkiyo MATSUMOTOYousuke SEYAMA
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2006 Volume 70 Issue 9 Pages 2121-2130

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Abstract

We compared the dietary effects of dihomo-γ-linolenic acid (DGLA) contained in the DGLA oil produced by a fungus with γ-linolenic acid (GLA) on the fatty acid composition. Wistar rats were fed with three kinds of oil for two weeks as follows: (i) control group: corn oil; (ii) GLA group: borage oil; (iii) DGLA group: DGLA oil/safflower oil = 55:45. The DGLA concentrations in the liver, serum, and brain of the DGLA group were higher than those of the GLA oil group. We also examined the dose effect of DGLA. The DGLA levels in the liver, serum, and brain significantly increased with increasing dosage of DGLA in the diet. DGLA administration significantly increased the ratio of PGE1/PGE2 in the rat plasma. The mechanism for GLA administration to improve atopic eczema is thought to involve an increase in the concentration of DGLA metabolized from GLA, so these results suggest that the dietary effect of DGLA would be more dominant than GLA.

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© 2006 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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