Vasodilating Effect of Di-Peptides in Thoracic Aortas from Spontaneously Hypertensive Rats

Mitsuru TANAKA; Toshiro MATSUI; Yusuke USHIDA; Kiyoshi MATSUMOTO

doi:10.1271/bbb.60119

Food & Nutrition Science Notes

Vasodilating Effect of Di-Peptides in Thoracic Aortas from Spontaneously Hypertensive Rats

Mitsuru TANAKA, Toshiro MATSUI, Yusuke USHIDA, Kiyoshi MATSUMOTO

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Keywords: hypertension, ACE, vascular relaxation, small peptides, spontaneously hypertensive rat (SHR) aorta

JOURNAL FREE ACCESS

2006 Volume 70 Issue 9 Pages 2292-2295

DOI https://doi.org/10.1271/bbb.60119

View "Advance Publication" version (September 7, 2006).

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Abstract

In this study, we found that antihypertensive di-peptide Val-Tyr (VY) showed a vascular relaxation effect in KCl-induced contraction of thoracic aorta rings from 18-week-old spontaneously hypertensive rats among di-peptides of VY, Ile-Tyr, and Tyr-Val irrespective of their angiotensin I-converting enzyme inhibitory activity. The effect was endothelium-independent, and was closely associated with vascular responses in the vascular smooth muscle layer.

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