A Tyrosinase Inhibitor, Daedalin A, from Mycelial Culture of Daedalea dickinsii

Keiji MORIMURA; Chihiro YAMAZAKI; Yasunao HATTORI; Hidefumi MAKABE; Tsunashi KAMO; Mitsuru HIROTA

doi:10.1271/bbb.70266

Organic Chemistry Notes

A Tyrosinase Inhibitor, Daedalin A, from Mycelial Culture of Daedalea dickinsii

Keiji MORIMURA, Chihiro YAMAZAKI, Yasunao HATTORI, Hidefumi MAKABE, Tsunashi KAMO, Mitsuru HIROTA

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Keywords: Daedalea dickinsii, chromene, tyrosinase, antioxidant

JOURNAL FREE ACCESS

2007 Volume 71 Issue 11 Pages 2837-2840

DOI https://doi.org/10.1271/bbb.70266

View "Advance Publication" version (November 7, 2007).

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Abstract

A chromene-type compound, daedalin A (1), was isolated from mycelial culture broth of Daedalea dickinsii. Based on spectroscopic data, the structure of 1 was found to be (2R)-6-hydroxy-2-hydroxymethyl-2-methyl-2H-chromene. Daedalin A (1) strongly inhibited the activity of tyrosinase (IC₅₀: 194 μM). In addition, 1 also showed 1,1-diphenyl-2-picrylhydrazyl scavenging activity (IC₅₀: 16.9 μM) and superoxide anion scavenging activity (IC₅₀: 28.5 μM).

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