Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Biochemistry & Molecular Biology Note
Accelerated Chronological Aging of a Mutant Fission Yeast Deficient in Both Glutathione and Superoxide Dismutase Having Cu and Zn as Cofactors and Its Enhancement by Sir2 Deficiency
Norihiro MUTOHSatoko KITAJIMA
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JOURNALS FREE ACCESS

2007 Volume 71 Issue 11 Pages 2841-2844

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Abstract

A mutant of Schizosaccharomyces pombe deficient in both superoxide dismutase with copper and zinc as cofactors and glutathione was hypersensitive to menadione, which intracellularly generates superoxide radicals, and showed short chronological lifespan with more oxidation of proteins. Disruption of the sir2 gene in the double mutant enhanced the short chronological lifespan without more enhanced protein oxidation.

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© 2007 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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