A Concise Synthetic Approach to β,γ-Dehydrocurvularin: Synthesis of (±)-Di-O-Methyl-β,γ-dehydrocurvularin

Abstract

A concise synthesis of di-O-methyl-β,γ-dehydrocurvularin, the di-O-methylated derivative of the naturally occurring nematicidal macrolide, β,γ-dehydrocurvuralin, was accomplished by starting from a commercially available aromatic carboxylic acid in a three-step sequence consisting of esterification, Friedel-Crafts acylation, and microwave-promoted ring-closing metathesis.