Three New Taxanes with the 10-Alkoxy Group from the Heartwood of Taxus cuspidata

Mei DONG; Man-Li ZHANG; Yu-Fang WANG; Xi-Ping ZHANG; Cun-Fang LI; Qing-Wen SHI; Bin CONG; Hiromasa KIYOTA

doi:10.1271/bbb.70210

Organic Chemistry Notes

Three New Taxanes with the 10-Alkoxy Group from the Heartwood of Taxus cuspidata

Mei DONG, Man-Li ZHANG, Yu-Fang WANG, Xi-Ping ZHANG, Cun-Fang LI, Qing-Wen SHI, Bin CONG, Hiromasa KIYOTA

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Keywords: Taxus cuspidata, Taxaceae, yew, taxane, alkoxy taxanes

JOURNAL FREE ACCESS

2007 Volume 71 Issue 8 Pages 2087-2090

DOI https://doi.org/10.1271/bbb.70210

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Abstract

Three novel taxanes with the 10-alkoxy group were isolated from heartwood of Taxus cuspidata. The structures were identified as 2α,14β-diacetoxy-10β-ethoxytaxa-11,4(20)-dien-5α-ol (1), 2α,14β-diacetoxy-10β-methoxytaxa-11,4(20)-dien-5α-ol (2), and 2α-acetoxy-10β-ethoxytaxa-11,4(20)-diene-5α,14β-diol (3) on the basis of spectroscopic analysis. These are the first taxanes with an alkoxy moiety on the skeleton.

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