Machilin G and Four Neolignans from Young Fruits of Magnolia denudata Show Various Degrees of Inhibitory Activity on Nitric Oxide (NO) Production

Toshiro NOSHITA; Shinji FUNAYAMA; Tadayoshi HIRAKAWA; Yumi KIDACHI; Kazuo RYOYAMA

doi:10.1271/bbb.80327

Organic Chemistry Notes

Machilin G and Four Neolignans from Young Fruits of Magnolia denudata Show Various Degrees of Inhibitory Activity on Nitric Oxide (NO) Production

Toshiro NOSHITA, Shinji FUNAYAMA, Tadayoshi HIRAKAWA, Yumi KIDACHI, Kazuo RYOYAMA

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Keywords: Magnolia denudata, machilin G, denudatin, nitric oxide synthase, macrophage

JOURNAL FREE ACCESS

2008 Volume 72 Issue 10 Pages 2775-2778

DOI https://doi.org/10.1271/bbb.80327

View "Advance Publication" version (October 7, 2008).

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Abstract

Denudatin A and B, denudadione B, fargesone A and machilin G were isolated from Magnolia denudata. These compounds showed inhibitory effects on nitric oxide (NO) production in the lipopolysaccharide plus interferon-γ activated-murine macrophage cell line, J774.1. Some but not all of the inhibition of NO production by machilin G, and denudatin A and B was apparently through the decreased expression of the inducible NO synthase (iNOS) gene.

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