Antioxidant Activity of Butane Type Lignans, Secoisolariciresinol, Dihydroguaiaretic Acid, and 7,7′-Oxodihydroguaiaretic Acid

Satoshi YAMAUCHI; Toshiya MASUDA; Takuya SUGAHARA; Yuya KAWAGUCHI; Maya OHUCHI; Tatsushi SOMEYA; Jun AKIYAMA; Shiori TOMINAGA; Manami YAMAWAKI; Taro KISHIDA; Koichi AKIYAMA; Masafumi MARUYAMA

doi:10.1271/bbb.80461

Organic Chemistry Regular Papers

Antioxidant Activity of Butane Type Lignans, Secoisolariciresinol, Dihydroguaiaretic Acid, and 7,7′-Oxodihydroguaiaretic Acid

Satoshi YAMAUCHI, Toshiya MASUDA, Takuya SUGAHARA, Yuya KAWAGUCHI, Maya OHUCHI, Tatsushi SOMEYA, Jun AKIYAMA, Shiori TOMINAGA, Manami YAMAWAKI, Taro KISHIDA, Koichi AKIYAMA, Masafumi MARUYAMA

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Keywords: lignan, antioxidant activity, dihydroguaiaretic acid

JOURNAL FREE ACCESS

2008 Volume 72 Issue 11 Pages 2981-2986

DOI https://doi.org/10.1271/bbb.80461

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Abstract

The antioxidant activity of butane-type lignans was evaluated. Secoisolariciresinol (SECO) and dihydroguaiaretic acid (DGA) showed higher radical scavenging activity than that of 7,7′-dioxodihydroguaiaretic acid (ODGA). SECO and DGA inhibited the oxidation of unsaturated fatty acid. Both enantiomers of DGA were also lipoxygenase inhibitors, but neither enantiomer of SECO inhibited the lipoxygenase activity.

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