Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Notes
Zeatin Supplement Improves Scopolamine-Induced Memory Impairment in Mice
Mi Jeong KIMSoo Jung CHOISeung-Taik LIMHye Kyung KIMYoung Jun KIMHo-Geun YOONDong-Hoon SHIN
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2008 Volume 72 Issue 2 Pages 577-581


In this study, our aim was to clarify the ameliorative effects of zeatin, a development hormone in plants. Zeatin mitigated cognitive deficits and showed AChE inhibition in scopolamine (Scop)-induced mice following 21 d of zeatin treatment. After administration of Scop for 30 min, each mouse performed Y-maze and step-down latency tasks as a check on immediate against cognitive function. The results showed that zeatin administration attenuated Scop-induced memory damage and decreased AChE activity in the mice. This suggests that zeatin might be useful for protecting cognitive dysfunction, as well as for reducing the activation of AChE in dementia.

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© 2008 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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