Nuclear Swelling Occurs during Premature Senescence Mediated by MAP Kinases in Normal Human Fibroblasts

Yusuke KOBAYASHI; Risa SAKEMURA; Atsuko KUMAGAI; Emi SUMIKAWA; Michihiko FUJII; Dai AYUSAWA

doi:10.1271/bbb.70760

Biochemistry & Molecular Biology Notes

Nuclear Swelling Occurs during Premature Senescence Mediated by MAP Kinases in Normal Human Fibroblasts

Yusuke KOBAYASHI, Risa SAKEMURA, Atsuko KUMAGAI, Emi SUMIKAWA, Michihiko FUJII, Dai AYUSAWA

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Keywords: cellular senescence, nuclear swelling, MAP kinase, excess thymidine

JOURNAL FREE ACCESS

2008 Volume 72 Issue 4 Pages 1122-1125

DOI https://doi.org/10.1271/bbb.70760

View "Advance Publication" version (April 7, 2008).

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Abstract

Excess thymidine induced premature senescence in normal human fibroblasts (TIG-7), with induction of typical senescence markers. Nuclear swelling, as well as cell swelling, was clearly observed in these senescent cells. Simultaneous addition of MAP kinase inhibitors, U0126, SB203580, and SP60025, effectively suppressed induction of premature senescence and senescence markers.

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