Impact of Spermine on Down-Regulation of Th2 Cytokines in Peripheral Blood Mononuclear Cells from Cedar Pollinosis Subjects in Vitro

Mitsuharu MATSUMOTO; Hiroichi KIMATA; Yoshimi BENNO; Shigenori KAMIO

doi:10.1271/bbb.70795

Biochemistry & Molecular Biology Notes

Impact of Spermine on Down-Regulation of Th2 Cytokines in Peripheral Blood Mononuclear Cells from Cedar Pollinosis Subjects in Vitro

Mitsuharu MATSUMOTO, Hiroichi KIMATA, Yoshimi BENNO, Shigenori KAMIO

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Keywords: polyamine, spermine, Th1/Th2, cytokine, cedar pollinosis

JOURNAL FREE ACCESS

2008 Volume 72 Issue 6 Pages 1604-1606

DOI https://doi.org/10.1271/bbb.70795

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Abstract

The effects of spermine (SPM) on the production of Th1 and Th2 cytokines using peripheral blood mononuclear cells (PBMCs) derived from cedar pollinosis subjects were investigated. Th2 cytokines produced by PBMCs stimulated by 10 μM SPM was significantly lower than that in the controls. These findings indicate that blood SPM is an important factor in the Th1/Th2 balance.

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