Liver Injury Due to 3-Amino-1-methyl-5H-pyrido [4,3-b] indole (Trp-P-2) and Its Prevention by Miso

Hiroyuki SUZUKI; Hideyuki SONE; Ken KAWAMURA; Kazuo ISHIHARA

doi:10.1271/bbb.80253

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Food & Nutrition Science Notes

Liver Injury Due to 3-Amino-1-methyl-5H-pyrido [4,3-b] indole (Trp-P-2) and Its Prevention by Miso

Hiroyuki SUZUKI, Hideyuki SONE, Ken KAWAMURA, Kazuo ISHIHARA

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Keywords: 3-amino-1-methyl-5H-pyrido [4,3-b] indole (Trp-P-2), miso, liver injury

JOURNAL FREE ACCESS

2008 Volume 72 Issue 8 Pages 2236-2238

DOI https://doi.org/10.1271/bbb.80253

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Abstract

Trp-P-2(3-amino-1-methyl-5H-pyrido [4,3-b] indole) ingestion for 42 d by C3H/HeJJcl mice caused elevation of serum alanine transaminase (ALT) activity and several signs of liver injury. These alterations were not observed in mice fed the diet supplemented with 10% miso. This suggests a preventive effect of miso as to Trp-P-2 induced liver injury.

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